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Technion 2nd Year Student

Posted:October 9,2018 @10:59 am

Are non-caseating granulomas unique to sarcoidosis? Or do all auto-inflammatory causes of granulomas display non-caseating granulomas? Along the same lines, do all infectious causes of granulomas display caseating granulomas or is it only tuberculosis?

Marcel Brus-Ramer

Technion 2nd Year Student

Are non-caseating granulomas unique to sarcoidosis? Or do all auto-inflammatory causes of granulomas display non-caseating...

Posted: October 18, 2018 @12:00 am


The most common cause of all granuloma formation worldwide is tuberculosis. The formation of granulomas in tuberculosis is thought to be a physiological reaction to prevent the systemic spread of the causative pathogen, the mycobacterium. is immune response typically results in a caseating granuloma with signs of necrosis. Many other infectious agents can trigger granuloma formation as well as foreign body material such as beryllium, and inherited defects in neutrophil function (chronic granulomatous disease). In chronic inflammatory diseases and primary immunodeficiencies with chronic inflammation, the granulomas have not been associated with specific external agents. With the exception of granulomatosis with polyangiitis, these granulomas are non-caseating and typically observed in patients with sarcoidosis, Crohn’s disease and common variable immunodeficiency. Sarcoidosis remains a diagnosis of exclusion

Usmle step 1, Tuberculosis, Sarcoidosis, Granulomas

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Technion 2nd Year Student
Posted:October 9,2018 @10:59 am

Are non-caseating granulomas unique to sarcoidosis? Or do all auto-inflammatory causes of granulomas display non-caseating granulomas? Along the same lines, do all infectious causes of granulomas display caseating granulomas or is it only tuberculosis?

Marcel Brus-Ramer
Posted: October 18, 2018 @12:00 am
Technion 2nd Year Student

Are non-caseating granulomas unique to sarcoidosis? Or do all auto-inflammatory causes of...

The most common cause of all granuloma formation worldwide is tuberculosis. The formation of granulomas in tuberculosis is thought to be a physiological reaction to prevent the systemic spread of the causative pathogen, the mycobacterium. is immune response typically results in a caseating granuloma with signs of necrosis. Many other infectious agents can trigger granuloma formation as well as foreign body material such as beryllium, and inherited defects in neutrophil function (chronic granulomatous disease). In chronic inflammatory diseases and primary immunodeficiencies with chronic inflammation, the granulomas have not been associated with specific external agents. With the exception of granulomatosis with polyangiitis, these granulomas are non-caseating and typically observed in patients with sarcoidosis, Crohn’s disease and common variable immunodeficiency. Sarcoidosis remains a diagnosis of exclusion

Usmle step 1, Tuberculosis, Sarcoidosis, Granulomas